PSB-12062
PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4.
Product Specifications
CAS Number
[55476-47-6]
Product Name Alternative
N- (p-Methylphenylsulfonyl) phenoxazine
UNSPSC
12352005
Hazard Statement
H302
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PSB-12062.html
Purity
98.70
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=S(N1C2=C(C=CC=C2)OC3=CC=CC=C13)(C4=CC=C(C)C=C4)=O
Molecular Formula
C19H15NO3S
Molecular Weight
337.39
Precautions
H302
References & Citations
[1]Hernandez-Olmos V, et al. N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55 (22) :9576-88.|[2]Stokes L, et al. P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Front Pharmacol. 2017 May 23;8:291.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X4 Receptor
Available Sizes
Curated Selection
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