7-Ethoxyresorufin

7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2][3][4].

Product Specifications

CAS Number

[5725-91-7]

Product Name Alternative

Resorufin ethyl ether

UNSPSC

12171500

Hazard Statement

H315, H319, H335

Target

Cytochrome P450; NO Synthase

Type

Dye Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/7-ethoxyresorufin.html

Purity

99.61

Solubility

DMF : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=CC2=NC3=C(C=C(OCC)C=C3)OC2=C1

Molecular Formula

C14H11NO3

Molecular Weight

241.24

Precautions

H315, H319, H335

References & Citations

[1]C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118 (1) :57-62.|[2]Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.|[3]Grafstöm R, et al. Inhibitors of 7-ethoxyresorufin and 7-ethoxycoumarin de-ethylases in rat small intestinal microsomes and cells. Drug Chem Toxicol. 1981;4 (2) :147-59.|[4]Pohl RJ, et al. A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions. Anal Biochem. 1980 Sep 1;107 (1) :150-5.