Dolcanatide
Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2].
Product Specifications
CAS Number
1092457-65-2
UNSPSC
12352209
Target
Guanylate Cyclase
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dolcanatide.html
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](N)CC(N)=O)=O)=O)N[C@](CSSC[C@@](NC([C@@H](NC([C@@H](NC1=O)C(C)C)=O)C)=O)([H])C(N[C@@](C(NCC(N2)=O)=O)([H])[C@H](O)C)=O)([H])C(N[C@H](C(N[C@@](C(N[C@](CSSC[C@H]2C(N[C@@H](C(O)=O)CC(C)C)=O)([H])C(N[C@H](C(N[C@H]1CC(N)=O)=O)C(C)C)=O)=O)([H])CC(C)C)=O)CCC(O)=O)=O
Molecular Formula
C65H104N18O26S4
Molecular Weight
1681.89
References & Citations
[1]Boulete IM, et al. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol. 2018 May 7;24 (17) :1888-1900.|[2]Shailubhai K, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6 (4) :213-22.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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