Tubulysin A

Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I) . Tubulysin A can synthesize ADC as ADC Cytotoxin[1][2][3][4].

Product Specifications

CAS Number

[205304-86-5]

Product Name Alternative

TubA

UNSPSC

12352203

Hazard Statement

H301, H311, H315, H319, H331, H335

Target

ADC Payload; Antibiotic; Microtubule/Tubulin; Mitosis

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Tubulysin-A.html

Purity

99.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O

Molecular Formula

C43H65N5O10S

Molecular Weight

844.07

Precautions

H301, H311, H315, H319, H331, H335

References & Citations

[1]Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396 (2) :235-42.|[2]Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) . 2000 Sep;53 (9) :879-85.|[3]Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7 (4) :678-83.|[4]Schluep T, et al. Polymeric tubulysin-peptide nanoparticles with potent antitumor activity. Clin Cancer Res. 2009 Jan 1;15 (1) :181-9.