2-Thiouracil
2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments[1][2][3].
Product Specifications
CAS Number
141-90-2
Product Name Alternative
Thiouracil
UNSPSC
12352005
Hazard Statement
H351
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/2-thiouracil.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)
Smiles
O=C(C=CN1)NC1=S
Molecular Formula
C4H4N2OS
Molecular Weight
128.16
Precautions
H351
References & Citations
[1]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485 (2-3) : p. 109-12.|[2]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39 (26) : p. 5192-201.|[3]Woodstock L, et al. The effect of 2-thiouracil on the growth of cells in the root. Annals of Botany, 1963, 27 (3) : 403-414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NNOS
Available Sizes
Frequently Asked Questions
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