2-Thiouracil

2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments[1][2][3].

Product Specifications

CAS Number

[141-90-2]

Product Name Alternative

Thiouracil

UNSPSC

12352005

Hazard Statement

H351

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/2-thiouracil.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)

Smiles

O=C(C=CN1)NC1=S

Molecular Formula

C4H4N2OS

Molecular Weight

128.16

Precautions

H351

References & Citations

[1]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485 (2-3) : p. 109-12.|[2]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39 (26) : p. 5192-201.|[3]Woodstock L, et al. The effect of 2-thiouracil on the growth of cells in the root. Annals of Botany, 1963, 27 (3) : 403-414.