2-Thiouracil
2-Thiouracil (Thiouracil) is a selective neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 20 μM. 2-Thiouracil antagonizes BH4-induced nNOS dimerization. 2-Thiouracil is also an antithyroid compound and a highly specific melanoma detector. 2-Thiouracil stimulates the growth of pea and corn root segments[1][2][3].
Product Specifications
CAS Number
141-90-2
Product Name Alternative
Thiouracil
UNSPSC
12352005
Hazard Statement
H351
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/2-thiouracil.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 0.67 mg/mL (ultrasonic)
Smiles
O=C(C=CN1)NC1=S
Molecular Formula
C4H4N2OS
Molecular Weight
128.16
Precautions
H351
References & Citations
[1]Palumbo, A., et al. 2-thiouracil is a selective inhibitor of neuronal nitric oxide synthase antagonising tetrahydrobiopterin-dependent enzyme activation and dimerisation. FEBS Lett, 2000. 485 (2-3) : p. 109-12.|[2]Napolitano, A., et al., Mechanism of selective incorporation of the melanoma seeker 2-thiouracil into growing melanin. J Med Chem, 1996. 39 (26) : p. 5192-201.|[3]Woodstock L, et al. The effect of 2-thiouracil on the growth of cells in the root. Annals of Botany, 1963, 27 (3) : 403-414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NNOS
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY421064 100 µg
TSPAN11 (NM_001080509) Human Over-expression Lysate
Sign In for Pricing
View Details 
CCG-1011-40 1 mL
Gal b(1,3)GalNac b-O-BSA Colloidal Gold Conjugate, 1mL 40nm
Sign In for Pricing
View Details ![CD272 (BTLA) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2G8]](https://cdn.genprice.uk/products/937/68dd1b70061270361ea18395/imageurl/ta505689am.webp)
TA505689AM 100 µL
CD272 (BTLA) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI2G8]
Sign In for Pricing
View Details 