PF-05381941
Product Specifications
UNSPSC Description
PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1].
Target Antigen
MAP3K; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-05381941.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC=NC=C2)C(C)=C1)NC3=CC(C(C)(C)C)=NN3C4=CC=CC(C#N)=C4
Molecular Weight
466.53
References & Citations
[1]Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120823/PF-05381941-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120823/PF-05381941-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1474022-02-0
Available Sizes
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