PF-05381941

PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1].

MAP3K; p38 MAPK

Reference compound

MAPK/ERK Pathway

Inflammation/Immunology

https://www.medchemexpress.com/pf-05381941.html

99.73

DMSO : 100 mg/mL (ultrasonic)

O=C(NC1=CC=C(OC2=CC=NC=C2)C(C)=C1)NC3=CC(C(C)(C)C)=NN3C4=CC=CC(C#N)=C4

466.53

[1]Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-120823/PF-05381941-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-120823/PF-05381941-SDS-MedChemExpress.pdf

No Development Reported

1474022-02-0