PhpC
PhpC is a G-quadruplex (G4) -DNA/RNA disruptor. PhpC disrupts DNA and RNA G4 structures and promotes G4 helicase activity. PhpC effectively enhancing the activity of Taq polymerase. PhpC modulates G-quadruplexs (G4s) both in vitro and in cells[1][2][3].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis; G-quadruplex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phpc.html
Purity
98.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCOC1=CC=CC(C2=CC3=CN(C(N=C3N2)=O)CC(OCC)=O)=C1
Molecular Formula
C18H20N4O4
Molecular Weight
356.38
References & Citations
[1]Liu X, et al. Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption. ACS Chem Biol. 2024 Sep 20;19 (9) :2032-2040. |[2]Mitteaux, J. et al. Identifying G-Quadruplex-DNA-Disrupting Small Molecules. J. Am. Chem. Soc. 143, 12567-12577 (2021) .|[3]Teng X, et al. Discovery of A G-Quadruplex Unwinder That Unleashes the Translation of G-Quadruplex-Containing mRNA without Inducing DNA Damage. Angew Chem Int Ed Engl. 2024 Sep 16;63 (38) :e202407353.|[4]Alexandre D, et al. Cellular modulation of a G-quadruplex structure found in the lung cancer-related microRNA-3196. Int J Biol Macromol. 2025 Jul;318 (Pt 4) :145263. |[5]De Magis, A. et al. UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence. Nat. Commun. 14, 6705 (2023) . |[6]Mitteaux J, et al. PhpC modulates G-quadruplex-RNA landscapes in human cells. Chem Commun (Camb) . 2024 Jan 4;60 (4) :424-427. |[7]Sharma S, et al. Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer. BMC Biol. 2025 Aug 8;23 (1) :249.|[8]M J VK, et al. Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems. J Biol Chem. 2025 Jan;301 (1) :108040.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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