PhpC

PhpC is a G-quadruplex (G4) -DNA/RNA disruptor. PhpC disrupts DNA and RNA G4 structures and promotes G4 helicase activity. PhpC effectively enhancing the activity of Taq polymerase. PhpC modulates G-quadruplexs (G4s) both in vitro and in cells[1][2][3].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis; G-quadruplex

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/phpc.html

Purity

98.90

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NCCOC1=CC=CC(C2=CC3=CN(C(N=C3N2)=O)CC(OCC)=O)=C1

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

References & Citations

[1]Liu X, et al. Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption. ACS Chem Biol. 2024 Sep 20;19 (9) :2032-2040. |[2]Mitteaux, J. et al. Identifying G-Quadruplex-DNA-Disrupting Small Molecules. J. Am. Chem. Soc. 143, 12567-12577 (2021) .|[3]Teng X, et al. Discovery of A G-Quadruplex Unwinder That Unleashes the Translation of G-Quadruplex-Containing mRNA without Inducing DNA Damage. Angew Chem Int Ed Engl. 2024 Sep 16;63 (38) :e202407353.|[4]Alexandre D, et al. Cellular modulation of a G-quadruplex structure found in the lung cancer-related microRNA-3196. Int J Biol Macromol. 2025 Jul;318 (Pt 4) :145263. |[5]De Magis, A. et al. UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence. Nat. Commun. 14, 6705 (2023) . |[6]Mitteaux J, et al. PhpC modulates G-quadruplex-RNA landscapes in human cells. Chem Commun (Camb) . 2024 Jan 4;60 (4) :424-427. |[7]Sharma S, et al. Pharmacomodulation of G-quadruplexes in long non-coding RNAs dysregulated in colorectal cancer. BMC Biol. 2025 Aug 8;23 (1) :249.|[8]M J VK, et al. Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems. J Biol Chem. 2025 Jan;301 (1) :108040.