MAO-B-IN-30

MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease[1].

Product Specifications

CAS Number

[82973-15-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mao-b-in-30.html

Purity

98.53

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(/C1=N\NC(C2=CC=C(Br)C=C2)=O)NC3=C1C=CC=C3

Molecular Formula

C15H10BrN3O2

Molecular Weight

344.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Kumar S, Oh JM, Prabhakaran P, Awasti A, Kim H, Mathew B. Isatin-tethered halogen-containing acylhydrazone derivatives as monoamine oxidase inhibitor with neuroprotective effect. Sci Rep. 2024 Jan 13;14 (1) :1264.