CDK2 degrader 1
CDK2 degrader 1 (Compound 3) is a selective CDK2 molecular glue degrader with a Dmax (CDK2) of > 80% and a Ki (CRBN) > 1 μM. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers[1].
Product Specifications
CAS Number
[3036604-59-5]
UNSPSC
12352005
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-degrader-1.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@](C1)(CC2)C[C@]2([H])[C@@H]1COC(NC3CN(C4=CC(F)=C(C5C(NC(CC5)=O)=O)C(F)=C4)C3)=O
Molecular Formula
C23H27F2N3O4
Molecular Weight
447.47
References & Citations
[1]Fasching B, et al. Compounds that mediate protein degradation and methods of use thereof[J]. US patent WO2023069700A1, 2022.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ERMP1, CT (ERMP1, FXNA, KIAA1815, Endoplasmic reticulum metallopeptidase 1, Felix-ina) (MaxLight 750) discontinued
