BC-1215

BC-1215 is a F-box protein 3 (Fbxo3) inhibitor. BC-1215 works by antagonizing of Fbxo3 on TRAF cytokine signaling and exhibits a low IC50 in vitro. BC-1215 can be used for the research of inflammation[1].

Product Specifications

CAS Number

[1507370-20-8]

Product Name Alternative

TPEDA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bc-1215.html

Purity

99.94

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1(CNCCNCC2=CC=C(C3=NC=CC=C3)C=C2)=CC=C(C4=NC=CC=C4)C=C1

Molecular Formula

C26H26N4

Molecular Weight

394.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen BB, et al. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulateinflammation. Nat Immunol. 2013 May;14 (5) :470-9.