Alverine (citrate)
Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.
Product Specifications
CAS Number
5560-59-8
Product Name Alternative
NSC 35459
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Alverine-citrate.html
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C26H35NO7
Molecular Weight
473.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53 (10) : p. 1419-26.|[2]Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152 (8) : p. 1228-38.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
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