Alverine (citrate)

Alverine citrate is a 5-HT1A receptor antagonist, with an IC50 of 101 nM.

Product Specifications

CAS Number

[5560-59-8]

Product Name Alternative

NSC 35459

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Alverine-citrate.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCN(CCCC1=CC=CC=C1)CCCC2=CC=CC=C2.O=C(CC(C(O)=O)(O)CC(O)=O)O

Molecular Formula

C26H35NO7

Molecular Weight

473.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Coelho, A.M., et al., Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype. J Pharm Pharmacol, 2001. 53 (10) : p. 1419-26.|[2]Hayase, M., et al., Evolving mechanisms of action of alverine citrate on phasic smooth muscles. Br J Pharmacol, 2007. 152 (8) : p. 1228-38.