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A-3 (hydrochloride)

Product Specifications

UNSPSC Description

A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM). A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1].

Target Antigen

CaMK; Casein Kinase; PKA; PKC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Epigenetics;Neuronal Signaling;Stem Cell/Wnt;TGF-beta/Smad

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/a-3-hydrochloride.html

Purity

99.75

Solubility

DMSO : 125 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl

Molecular Weight

321.22

References & Citations

[1]Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29(6):577-81.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-125957/A-3-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-125957/A-3-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

78957-85-4

Available Sizes

Curated Selection

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