What is the catalog number for Pinostrobin?

The catalog number for Pinostrobin is HY-N2127.

What sizes are available for Pinostrobin?

Pinostrobin is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does Pinostrobin come in?

Pinostrobin is available in 2 different pack sizes.

Is Pinostrobin in stock?

Pinostrobin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Pinostrobin?

Pinostrobin is manufactured by QuantiMol.

What is the estimated delivery time for Pinostrobin?

Estimated delivery time for Pinostrobin is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Pinostrobin?

The safety data sheet for Pinostrobin is available here: http://file.medchemexpress.com/batch_PDF/HY-N2127/Pinostrobin-SDS-MedChemExpress.pdf.

Pinostrobin

Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

480-37-5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β; Apoptosis; HSV; Interleukin Related; Ser/Thr Protease

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pinostrobin.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=CC=C2)OC3=CC(OC)=CC(O)=C13

Molecular Formula

C16H14O4

Molecular Weight

270.28

Precautions

H315, H319, H335

References & Citations

[1]Gao WY, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells.J Agric Food Chem. 2018 Jun 20;66 (24) :6083-6093.|[2]Wu N, et al. Activity investigation of pinostrobin towards herpes simplex virus-1 as determined by atomic force microscopy. Phytomedicine. 2011 Jan 15;18 (2-3) :110-8. |[3]Patel NK, et al. Pinostrobin and Cajanus lactone isolated from Cajanus cajan (L.) leaves inhibits TNF-α and IL-1β production: in vitro and in vivo experimentation. Phytomedicine. 2014 Jun 15;21 (7) :946-53. |[4]Shareef SH, et al. Hepatoprotective effect of pinostrobin against thioacetamide-induced liver cirrhosis in rats. Saudi J Biol Sci. 2023 Jan;30 (1) :103506.|[5]Yoon JH, et al. Discovery of Pinostrobin as a Melanogenic Agent in cAMP/PKA and p38 MAPK Signaling Pathway. Nutrients. 2022 Sep 9;14 (18) :3713. |[6]Norkaew C, et al. Pinostrobin induces acute leukemia cell apoptosis via the regulation of miR-410-5p and SFRP5. Life Sci. 2023 Jul 15;325:121739. |[7]Jaudan A, et al. Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action. PLoS One. 2018 Feb 8;13 (2) :e0191523. |[8]Hua X, et al. Determination of pinostrobin in rat plasma by LC-MS/MS: application to pharmacokinetics. J Pharm Biomed Anal. 2011 Dec 5;56 (4) :841-5.