Quinolinic acid
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis[1][2][3][4][5][6][7][8].
Product Specifications
CAS Number
89-00-9
UNSPSC
12352005
Hazard Statement
H319, H335
Target
Apoptosis; Endogenous Metabolite; iGluR; NO Synthase; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Quinolinic_acid.html
Purity
99.88
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC=C1C(O)=O)O
Molecular Formula
C7H5NO4
Molecular Weight
167.12
Precautions
H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite; NMDA Receptor
Available Sizes
Frequently Asked Questions
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