Quinolinic acid

Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[89-00-9]

UNSPSC

12352005

Hazard Statement

H319, H335

Target

Apoptosis; Endogenous Metabolite; iGluR; NO Synthase; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Quinolinic_acid.html

Purity

99.88

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=CC=C1C(O)=O)O

Molecular Formula

C7H5NO4

Molecular Weight

167.12

Precautions

H319, H335

References & Citations

[1]Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 (Pt 5) :1249-73.|[2]Jang S, et al. Neuroprotective effects of (-) -epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33.|[3]Sugisawa E, et al. Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia. Cell Rep. 2022 Mar 8;38 (10) :110462.|[4]Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7.|[5]Lapin IP. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm. 1978;42 (1) :37-43.|[6]Goel F, et al. Protective effects of diacerein against quinolinic acid-induced Huntington's disease-like symptoms in adult zebrafish by targeting GSK-3β signalling. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug;398 (8) :10799-10821.|[7]Bains M, et al. Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway. Eur J Pharmacol. 2022 Nov 5;934:175316.|[8]Martínez-Gopar PE, et al. Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid-induced model of Huntington's disease. J Neurochem. 2022 Jan;160 (2) :256-270.