Z-VDVAD-FMK
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3].
Product Specifications
CAS Number
210344-92-6
Product Name Alternative
Z-VD (OMe) VAD (OMe) -FMK
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-vdvad-fmk.html
Purity
98.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C(C)C)C(N[C@@H](CC(OC)=O)C(N[C@H](C(N[C@@H](C)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)C(C)C)=O)=O)OCC1=CC=CC=C1
Molecular Formula
C32H46FN5O11
Molecular Weight
695.73
References & Citations
[1]S Gamen, et al. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes deltapsim loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp Cell Res. 2000 Jul 10;258 (1) :223-35. |[2]Cédric Sapet, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006 Sep 15;108 (6) :1868-76. |[3]Simon W Rabkin, et al. Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors. Toxicol Appl Pharmacol. 2003 Dec 15;193 (3) :346-55.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 2
Available Sizes
Frequently Asked Questions
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