N-Acetyl-L-methionine

N-Acetyl-L-methionine is a dietary supplementation. N-Acetyl-L-methionine increases caspase-3 activity and inhibits mitochondrial activity. N-Acetyl-L-methionine promotes lactation and improves meat quality[1][2][3][4][5][6].

Product Specifications

CAS Number

[65-82-7]

Product Name Alternative

N-Acetylmethionine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Caspase; Mitochondrial Metabolism

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/n-acetyl-l-methionine.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CSCC[C@H](NC(C)=O)C(O)=O

Molecular Formula

C7H13NO3S

Molecular Weight

191.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Ball RO, et al. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136 (6 Suppl) :1682S-1693S.|[2]Kouno Y, et al. N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan. Biochem Biophys Rep. 2016 Apr 26;6:266-274. |[3]Greilberger J, et al. The Influence of N-Acetyl-selenomethionine on Two RONS-Generating Cancer Cell Lines Compared to N-Acetyl-methionine. Cells. 2024 May 29;13 (11) :937.|[4]Fagundes MA, et al. Influence of supplementing a methionine derivative, N-acetyl-l-methionine, in dairy diets on production and ruminal fermentation by lactating cows during early to mid lactation. J Dairy Sci. 2018 Aug;101 (8) :7082-7094.|[5]Liu Y, et al. N-acetyl-l-methionine dietary supplementation improves meat quality by oxidative stability of finishing Angus heifers. Meat Sci. 2024 Aug;214:109499. |[6]Rotruck JT, et al. Effects of excess dietary l-methionine and N-acetyl-l-methionine on growing rats. J Nutr. 1977 Mar;107 (3) :357-62.