IMB-301
IMB-301 is a specific HIV-1 replication inhibitor that binds to hA3G (human APOBEC3G), interrupts the hA3G-Vif interaction and inhibits Vif-mediated degradation of hA3G. IMB-301 inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM) . Human APOBEC3G is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication[1].
Product Specifications
CAS Number
[64009-84-3]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/imb-301.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(OCCC(C2=CC=C(Cl)C=C2Cl)CN3C=CN=C3)C=C1
Molecular Formula
C19H17Cl2FN2O
Molecular Weight
379.26
References & Citations
[1]Ma L, et al. Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep. 2018;8 (1) :8067. Published 2018 May 23.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
Available Sizes
Curated Selection
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