[Leu15]-Gastrin I (human)

[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer[1][2][3][4].

Product Specifications

CAS Number

[39024-57-2]

UNSPSC

12352209

Target

Cholecystokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/leu15-gastrin-i-human.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 10.53 mg/mL (ultrasonic; adjust pH to 11 with NaOH)

Smiles

O=C([C@H]1N(CCC1)C(CNC([C@H]2NC(CC2)=O)=O)=O)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)CC6=CC=C(C=C6)O)=O)=O)=O)=O)=O)=O)=O)=O)CC7=CNC8=CC=CC=C78

Molecular Formula

C98H126N20O31

Molecular Weight

2080.16

References & Citations

[1]Kleomenis Barlos, et al. Veresterung von partiell geschützten peptid-fragmenten mit harzen. Einsatz von 2-chlortritylchlorid zur synthese von Leu15 -gastrin I[J]. Tetrahedron Letters, 1989.|[2]Smith JP, et al. Gastrin and Gastric Cancer. Cell Mol Gastroenterol Hepatol. 2017 Mar 14;4 (1) :75-83. |[3]Barlos K, et al. Application of 2-chlorotrityl resin in solid phase synthesis of (Leu15) -gastrin I and unsulfated cholecystokinin octapeptide. Selective O-deprotection of tyrosine. Int J Pept Protein Res. 1991 Dec;38 (6) :555-61. |[4]Reubi JC, et al. Localization of cholecystokinin A and cholecystokinin B-gastrin receptors in the human stomach. Gastroenterology. 1997 Apr;112 (4) :1197-205.