Q134R

Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research[1].

Product Specifications

CAS Number

[2022949-46-6]

UNSPSC

12352005

Target

Nuclear Factor of activated T Cells (NFAT)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/q134r.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(N=CC=C2)C2=CC=C1[C@@H](C3=CC=C(C(F)(F)F)C=C3)NC4=NC=CC(C)=N4

Molecular Formula

C22H17F3N4O

Molecular Weight

410.39

References & Citations

[1]Pradoldej Sompol, et al. Q134R: Small chemical compound with NFAT inhibitory properties improves behavioral performance and synapse function in mouse models of amyloid pathology. Aging Cell. 2021 Jul;20 (7) :e13416.