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ELOVL6-IN-5

ELOVL6-IN-5 (compound B) is an inhibitor of the elongase enzyme of long-chain fatty acid family 6 (ELOVL6) . ELOVL6 is a rate-limiting enzyme for the elongation of saturated and monounsaturated long-chain fatty acids and is an effective target for inhibiting diabetes. ELOVL6-IN-5 reduces hepatic fatty acid levels in a mouse model of diet-induced obesity (DIO) . However, ELOVL6 inhibition by ELOVL6-IN-5 did not improve insulin resistance[1].

Product Specifications

CAS Number

1135000-36-0

UNSPSC

12352005

Target

ELOVL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/elovl6-in-5.html

Purity

95.12

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(N1C2CCC1CC(S(=O)(C3=NC=CC=C3)=O)C2)NC4=CC=C(C(F)(F)F)C=C4

Molecular Formula

C20H20F3N3O3S

Molecular Weight

439.45

References & Citations

[1]Shimamura K, et al. Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6. Eur J Pharmacol. 2010 Mar 25;630 (1-3) :34-41.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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