Emlenoflast (sodium)
Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of [1][2].
Product Specifications
CAS Number
[2380032-29-9]
Product Name Alternative
MCC7840 (sodium)
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mcc7840-sodium.html
Purity
98.31
Solubility
DMSO : 240 mg/mL (ultrasonic)
Smiles
O=S(C1=NN(C(C)C)C=C1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Molecular Formula
C19H23N4NaO3S
Molecular Weight
410.47
References & Citations
[1]El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25 (23) :5533.|[2]O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
Curated Selection
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