(R) -BPO-27

(R) -BPO-27, the R enantiomer of BPO-27, is a potent, orally active and ATP-competitive CFTR inhibitor with an IC50 of 4 nM.

Product Specifications

CAS Number

[1415390-47-4]

UNSPSC

12352005

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/_R_-BPO-27.html

Purity

99.94

Solubility

DMSO : ≥ 14.28 mg/mL

Smiles

O=C(C1=CC=C(O[C@@H](C2=CC=C(Br)O2)C3=C(N(C)C4=O)C(C(N4C)=O)=C(C5=CC=CC=C5)N36)C6=C1)O

Molecular Formula

C26H18BrN3O6

Molecular Weight

548.34

References & Citations

[1]Snyder DS, et al. Absolute Configuration And Biological Properties of Enantiomers of CFTR Inhibitor BPO-27. ACS Med Chem Lett. 2013 May 9;4 (5) :456-459.|[2]Kim Y, et al. Benzopyrimido-pyrrolo-oxazine-dione (R) -BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88 (4) :689-96.|[3]Onur Cil, et al.Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R) -BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 Feb;31 (2) :751-760.