(24E) -3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
Selected Variant
HY-N1783
Size: 1 mg
(24E) -3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor, with an IC50 of 0.4 μM. (24E) -3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid exhibits potent PTP1B inhibitory activity without cytotoxicity[1].
Product Specifications
CAS Number
329975-47-5
UNSPSC
12352211
Target
Phosphatase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/24e-3-4-secocucurbita-4-24-diene-3-26-29-trioic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC[C@@H]([C@@]1(C)[C@]2([H])[C@]3(C)CC[C@@]([C@H](C)CC/C=C(C(O)=O)\C)(C)[C@@]3(C)CC1)/C(CC2)=C(C(O)=O)\C
Molecular Formula
C31H48O6
Molecular Weight
516.71
References & Citations
[1]Maarisit W, et al. Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida. J Nat Med. 2017 Jan;71 (1) :334-337.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Price
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