Istaroxime (oxalate)

Istaroxime oxalate (PST2744 oxalate) is the oxalate form of Istaroxime (HY-15718) . Istaroxime oxalate is is an inotropic agent, that inhibits Na+/K+-ATPase with an IC50 of 0.11 μM. Istaroxime oxalate increases force of contraction in guinea pig atria and twitch amplitude in isolated guinea pig myocytes without causing lethal arrhythmias[1][2].

Product Specifications

CAS Number

[203737-94-4]

Product Name Alternative

PST2744 (oxalate)

UNSPSC

12352211

Target

Na+/K+ ATPase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/istaroxime-oxalate.html

Smiles

O=C1CC[C@@]2([H])[C@]3([H])CC([C@@]4([H])C/C(CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=N/OCCN)=O.OC(C(O)=O)=O

Molecular Formula

C23H34N2O7

Molecular Weight

450.53

References & Citations

[1]Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na (+), K (+) -ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch|[2]Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E, Z) -3- ((2-aminoethoxy) imino) androstane-6,17-dione hydrochloride (PST2744) . J Pharmacol Exp Ther. 2002 Nov;303 (2) :592-600.