PF-3644022

PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect[1].

Product Specifications

CAS Number

[1276121-88-0]

UNSPSC

12352005

Hazard Statement

H302, H319, H413

Target

MAPKAPK2 (MK2) ; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pf-3644022.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2

Molecular Formula

C21H18N4OS

Molecular Weight

374.46

Precautions

H302, H319, H413

References & Citations

[1]Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333 (3) :797-807