Mozavaptan (hydrochloride)
Product Specifications
Product Name Alternative
OPC-31260 (hydrochloride)
UNSPSC Description
Mozavaptan hydrochloride (OPC-31260 hydrochloride) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan hydrochloride shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan hydrochloride has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment[1][2].
Target Antigen
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer; Endocrinology; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mozavaptan-hydrochloride.html
Purity
99.89
Solubility
DMSO : 20.83 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic)
Smiles
CC1=CC=CC=C1C(NC2=CC=C(C(N3C(C=CC=C4)=C4C(N(C)C)CCC3)=O)C=C2)=O.Cl
Molecular Weight
464.00
References & Citations
[1]Yamamura Y, et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br J Pharmacol. 1992 Apr;105(4):787-91.|[2]Yamaguchi K, et al. Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome. Jpn J Clin Oncol. 2011 Jan;41(1):148-52.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123593/Mozavaptan-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123593/Mozavaptan-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
138470-70-9
Available Sizes
Curated Selection
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