PARP-1-IN-2

PARP-1-IN-2 (compound 11g) is a potent and BBB-penetrated PARP1 inhibitor, with an IC50 of 149 nM. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1].

Product Specifications

CAS Number

[684234-55-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Caspase; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp-1-in-2.html

Purity

99.48

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(Cl)=C1)CN(N=C(C2=CC=C(Cl)C=C2)C3=C4C=CC=C3)C4=O

Molecular Formula

C22H15Cl2N3O2

Molecular Weight

424.28

Precautions

H315, H319

References & Citations

[1]Almahli H, et al. Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer. Bioorg Chem. 2018 Apr;77:443-456.