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ACHN-975 (TFA)

ACHN-975 TFA is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 TFA is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL) [1].

Product Specifications

CAS Number

1410809-37-8

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/achn-975-tfa.html

Purity

99.02

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](C(NO)=O)C(C)(N)C)C1=CC=C(C#CC#C[C@H]2[C@H](CO)C2)C=C1.O=C(O)C(F)(F)F

Molecular Formula

C22H24F3N3O6

Molecular Weight

483.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Kalinin DV, et al. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design. Curr Top Med Chem. 2016;16 (21) :2379-430.|[2]Krause KM, et al. Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa.Antimicrob Agents Chemother. 2019 Oct 22;63 (11) . pii: e00977-19.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Frequently Asked Questions

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