BIO-7488
BIO-7488 is an orally active, selective and blood-brain barrier permeable IRAK4 inhibitor, with an IC50 value of 0.5 nM. BIO-7488 inhibits the production of pro-inflammatory cytokines (IL-1β, TNFα, IL-6) and demonstrates anti-inflammatory effects in both LPS and distal hypoxic-middle cerebral artery occlusion (DH-MCAO) ischemic stroke model. BIO-7488 can be used for the study of neuroinflammatory-related diseases, particularly ischemic stroke[1].
Product Specifications
CAS Number
2573211-25-1
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bio-7488.html
Purity
99.44
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3
Molecular Formula
C23H25N7O3
Molecular Weight
447.49
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Retinoic Acid Receptor alpha (RARA) (NM_000964) Human Over-expression Lysate
![FOXP1 Mouse Monoclonal Antibody [Clone ID: OTI2H3]](https://cdn.genprice.uk/products/937/68dd1b88061270361ea214bf/imageurl/ta813710.webp)
Biotin Conjugated Sophora japonica (Pagoda Tree) -SJA-
![6,7-Dihydro-2-(1-pyrrolidinyl)-5H-pyrrolo[3,4-d]pyrimidine Dihydrochloride;](https://cdn.genprice.uk/products/572/8749843763172/imageurl/trc-p184751-1g.webp)
6,7-Dihydro-2-(1-pyrrolidinyl)-5H-pyrrolo[3,4-d]pyrimidine Dihydrochloride;
