Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

BIO-7488

BIO-7488 is an orally active, selective and blood-brain barrier permeable IRAK4 inhibitor, with an IC50 value of 0.5 nM. BIO-7488 inhibits the production of pro-inflammatory cytokines (IL-1β, TNFα, IL-6) and demonstrates anti-inflammatory effects in both LPS and distal hypoxic-middle cerebral artery occlusion (DH-MCAO) ischemic stroke model. BIO-7488 can be used for the study of neuroinflammatory-related diseases, particularly ischemic stroke[1].

Product Specifications

CAS Number

2573211-25-1

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bio-7488.html

Purity

99.44

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C2)OCC2(C1)C3=CN4C(N=C(OC(C)C)C(C(NC5=C(N=CC(C)=C6)N6N=C5)=O)=C4)=N3

Molecular Formula

C23H25N7O3

Molecular Weight

447.49

References & Citations

[1]Ryan Evans, et al. The Discovery of 7-Isopropoxy-2- (1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl) -N- (6-methylpyrazolo[1,5-a]pyrimidin-3-yl) imidazo[1,2-a]pyrimidine-6-carboxamide (BIO-7488), a Potent, Selective, and CNS-Penetrant IRAK4 Inhibitor for the Treatment of Ischemic Stroke. J.Med. Chem. 2024.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

TWIST2 Mouse Monoclonal Antibody [Clone ID: OTI9F11]
CF805301 100 µg

TWIST2 Mouse Monoclonal Antibody [Clone ID: OTI9F11]

Sign In for Pricing
View Details
CuLlin 4B (CuL4B) (NM_003588) Human Recombinant Protein
TP306935 20 µg

CuLlin 4B (CuL4B) (NM_003588) Human Recombinant Protein

Sign In for Pricing
View Details
GF-1 Plant II DNA Extraction Kit (Proteinase K included), 50 preps
GF-PT2-050 50 Preparations

GF-1 Plant II DNA Extraction Kit (Proteinase K included), 50 preps

Sign In for Pricing
View Details
Recombinant APC Monoclonal Antibody
E-AB-81529-01 50 µL

Recombinant APC Monoclonal Antibody

Sign In for Pricing
View Details
Recombinant APC Monoclonal Antibody
E-AB-81529-02 100 µL

Recombinant APC Monoclonal Antibody

Sign In for Pricing
View Details
Human Kappa Light Chain (B-Cell Marker) (rL1C1), CF488A conjugate, 0.1mg/mL
BNC882222-500 1x 500 µL

Human Kappa Light Chain (B-Cell Marker) (rL1C1), CF488A conjugate, 0.1mg/mL

Sign In for Pricing
View Details