NH2-PEG6-Boc

NH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].

Product Specifications

CAS Number

[1286281-32-0]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nh2-peg6-boc.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCN

Molecular Formula

C19H39NO8

Molecular Weight

409.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Foley CA, et al. Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS Chem Biol. 2020 Jan 17;15 (1) :290-295.|[2]Kenneth John DIRICO, et al. Spliceostatin analogs. WO2014068443A1.