ML188
ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity[1].
Product Specifications
CAS Number
1417700-13-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml188.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC(C)(C)C)[C@@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O
Molecular Formula
C26H31N3O3
Molecular Weight
433.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Jacobs J, et al. Discovery, synthesis, and structure-based optimization of a series of N- (tert-butyl) -2- (N-arylamido) -2- (pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24;56 (2) :534-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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