ML188

ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity[1].

Product Specifications

CAS Number

[1417700-13-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SARS-CoV; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ml188.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC(C)(C)C)[C@@H](C1=CN=CC=C1)N(C(C=C2)=CC=C2C(C)(C)C)C(C3=CC=CO3)=O

Molecular Formula

C26H31N3O3

Molecular Weight

433.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Jacobs J, et al. Discovery, synthesis, and structure-based optimization of a series of N- (tert-butyl) -2- (N-arylamido) -2- (pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24;56 (2) :534-46.