Rabbit anti Human Sphingosine 1-Phosphate Lyase 1

Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1-phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.

Antibody can be used for Western blotting (1:400 dilution). Other applications not yet tested. Optimal concentration should be evaluated by serial dilutions.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Van Veldhoven P.P., et al; Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22. Biochim. Biophys. Acta 1487:128-134(2000). 2. Reiss U., et al; Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J. Biol. Chem. 279:1281-1290(2004). 3. Nagase T., et al; Prediction of the coding sequences of unidentified Human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.; DNA Res. 6:337-345(1999). 4. Strausberg R.L., et al; Generation and initial analysis of more than 15,000 full-length Human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).