cGAS Recombinant Rabbit Monoclonal Antibody [PSH06-78]
Selected Variant
HA722736
Size: 100 µL
Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS are more vulnerable to lethal infection by DNA viruses and RNA viruses. In addition, cGAS has been shown to be an innate immune sensor of retroviruses including HIV. The human gene encoding cGAS is MB21D1 on chromosome 6.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
CGAS, C6orf150, MB21D1
Swiss Prot
Q8N884 Human
Cellular Locus
Nucleus, Chromosome, Cell membrane, Cytoplasm, cytosol.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human cGAS aa 101-522.
Isotype
IgG
Clone
PSH06-78
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB
Positive Control
THP-1 cell lysate, HT-29 cell lysate, NK-92 cell lysate, Caco-2 cell lysate, HeLa cell lysate, A431 cell lysate, LoVo cell lysate, PANC-1 cell lysate.
Concentration
1 mg/mL
Dilution
WB: 1:2,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 59 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
Price
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