KRAS inhibitor-9

KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].

Product Specifications

CAS Number

[300809-71-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-inhibitor-9.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC1=CC=C(SC2=NC3=CC=CC=C3S2)C(Cl)=C1

Molecular Formula

C13H9ClN2S2

Molecular Weight

292.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.