Tanzisertib
Tanzisertib (CC-930) is a potent JNK1/2/3 inhibitor with IC50s of 61/7/6 nM, respectively.
Product Specifications
CAS Number
899805-25-5
Product Name Alternative
CC-930
UNSPSC
12352005
Hazard Statement
H302
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cc-930.html
Purity
99.87
Solubility
1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 33 mg/mL
Smiles
O[C@H]1CC[C@H](NC2=NC=C3N=C(NC4=C(F)C=C(F)C=C4F)N([C@@H]5COCC5)C3=N2)CC1
Molecular Formula
C21H23F3N6O2
Molecular Weight
448.44
Precautions
H302
References & Citations
[1]Lay T Gan, et al. Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. J Hepatol. 2014 Dec;61 (6) :1376-84.|[2]Nicole Reich, et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis. 2012 May;71 (5) :737-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JNK1; JNK2; JNK3
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