Tanzisertib

Tanzisertib (CC-930) is a potent JNK1/2/3 inhibitor with IC50s of 61/7/6 nM, respectively.

Product Specifications

CAS Number

[899805-25-5]

Product Name Alternative

CC-930

UNSPSC

12352005

Hazard Statement

H302

Target

JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cc-930.html

Purity

99.87

Solubility

1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : ≥ 33 mg/mL

Smiles

O[C@H]1CC[C@H](NC2=NC=C3N=C(NC4=C(F)C=C(F)C=C4F)N([C@@H]5COCC5)C3=N2)CC1

Molecular Formula

C21H23F3N6O2

Molecular Weight

448.44

Precautions

H302

References & Citations

[1]Lay T Gan, et al. Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. J Hepatol. 2014 Dec;61 (6) :1376-84.|[2]Nicole Reich, et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis. 2012 May;71 (5) :737-45.