Sennidin A
Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].
Product Specifications
CAS Number
641-12-3
UNSPSC
12352005
Hazard Statement
H302
Target
Akt; GLUT; HCV
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/sennidin-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C35)=O)([H])C6=CC=CC(O)=C16
Molecular Formula
C30H18O10
Molecular Weight
538.46
Precautions
P264-P270-P330-P501
References & Citations
[1]Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16 (8) :18439-53.|[2]Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT4
Available Sizes
Frequently Asked Questions
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