Sennidin A

Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC50 of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation[1][2].

Product Specifications

CAS Number

[641-12-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; GLUT; HCV

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sennidin-a.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(O)C=C(C(O)=O)C=C2[C@@]([C@@]3([H])C4=CC(C(O)=O)=CC(O)=C4C(C5=C(O)C=CC=C35)=O)([H])C6=CC=CC(O)=C16

Molecular Formula

C30H18O10

Molecular Weight

538.46

Precautions

P264-P270-P330-P501

References & Citations

[1]Furuta A, et al. Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase. Int J Mol Sci. 2015 Aug 7;16 (8) :18439-53.|[2]Daigo Abe, et al. Sennidin stimulates glucose incorporation in rat adipocytes. Life Sciences. 2006.