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DCAF1 binder 1

DCAF1 binder 1 is a selective for the CRL4 DCAF1 E3 ligase complex. DCAF1 binder 1 is a ligands for E3 Ligase, involving in targeted protein degradation (TPD) [1].

Product Specifications

CAS Number

3053860-67-3

UNSPSC

12352005

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dcaf1-binder-1.html

Purity

99.12

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NCCNC1=NC(C2(C3=CC=C(C=C3)Cl)CCCCC2)=NC4=C1C=CC(N5CCN(CC5)C(C)=O)=C4

Molecular Formula

C28H35ClN6O

Molecular Weight

507.07

References & Citations

[1]Schroeder M, et al. Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings[J]. bioRxiv, 2023: 2023.04. 09.536153.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Available Sizes

Frequently Asked Questions

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