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CMKLR1 antagonist 1

CMKLR1 antagonist 1 (compound S-26d) is a potent and orally active chemokine-like receptor 1 (CMKLR1) antagonist, with a pIC50 value of 7.44 in hCMKLR1-transfected CHO cells. CMKLR1 antagonist 1 can be used for psoriasis and metabolic diseases research[1].

Product Specifications

CAS Number

[3033101-08-2]

UNSPSC

12352005

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cmklr1-antagonist-1.html

Concentration

10mM

Purity

99.44

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C[C@H](C)C1=CC=C(OCC(C=C2F)=CC3=C2C(C4=CC(Cl)=C(CO)C(Cl)=C4)=NN3C5CCCC5)C=C1)O

Molecular Formula

C30H29Cl2FN2O4

Molecular Weight

571.47

References & Citations

[1]Ko B, et al. Discovery of 3-Phenyl Indazole-Based Novel Chemokine-like Receptor 1 Antagonists for the Treatment of Psoriasis. J Med Chem. 2023 Oct 26.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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