TriGalNAc CBz
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies[1].
Product Specifications
CAS Number
186613-57-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
LYTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/trigalnac-cbz.html
Purity
98.73
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CC=C1)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)OCCCCC(O)=O)COC(C3=CC=CC=C3)=O)OC(C4=CC=CC=C4)=O
Molecular Formula
C34H35NO11
Molecular Weight
633.64
Precautions
H302, H315, H319
References & Citations
[1]Kallanthottathil G. Rajeev, et al. Compositions and methods for targeted rna delivery. WO2021178725.|[2]Biessen EA, Sliedregt-Bol K, 'T Hoen PA, et al. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem. 2002;13 (2) :295-302. |[3]Ahn G, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation[J]. Nature Chemical Biology, 2021, 17 (9) : 937-946.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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