TriGalNAc CBz

TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies[1].

Product Specifications

CAS Number

[186613-57-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

LYTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/trigalnac-cbz.html

Purity

98.73

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=CC=C1)O[C@H]2[C@H]([C@H](O[C@H]([C@@H]2NC(C)=O)OCCCCC(O)=O)COC(C3=CC=CC=C3)=O)OC(C4=CC=CC=C4)=O

Molecular Formula

C34H35NO11

Molecular Weight

633.64

Precautions

H302, H315, H319

References & Citations

[1]Kallanthottathil G. Rajeev, et al. Compositions and methods for targeted rna delivery. WO2021178725.|[2]Biessen EA, Sliedregt-Bol K, 'T Hoen PA, et al. Design of a targeted peptide nucleic acid prodrug to inhibit hepatic human microsomal triglyceride transfer protein expression in hepatocytes. Bioconjug Chem. 2002;13 (2) :295-302. |[3]Ahn G, et al. LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation[J]. Nature Chemical Biology, 2021, 17 (9) : 937-946.