Prinaberel
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3].
Product Specifications
CAS Number
524684-52-4
Product Name Alternative
ERB-041
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Apoptosis; Estrogen Receptor/ERR; Wnt
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Prinaberel.html
Purity
98.05
Solubility
DMSO : ≥ 40 mg/mL
Smiles
OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1
Molecular Formula
C15H10FNO3
Molecular Weight
271.24
Precautions
H302, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ERα; ERβ
Available Sizes
Frequently Asked Questions
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